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overall, we found that any use of diuretics combined with digoxin increased the risk of hospitalization for digoxin intoxication, and the risk was higher for combinations of diuretic classes.

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4 it may also induce p-glycoprotein pgp , which may affect drugs transported by pgp, such as digoxin.

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gregg fonarow, a professor of cardiology at the university of california, los angeles, said, although digoxin has been used for decades to treat patients with atrial fibrillation, there has been very limited clinical trial data, and its safety and effectiveness for atrial fibrillation remains controversial.

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enalapril is usually administered with furosemide and digoxin.

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